2014-04-01から1ヶ月間の記事一覧
J. Biochem 2013, 153(2):131-138 Introduciton 好気生物は代謝に酸素分子の化学的反応性を活用している。 ROSとは ROS毒性説 ROSが様々な疾患の病態に係わるが、抗酸化剤は期待されるほど有効で無い ROS産生系として、NoxとDuox ROSシグナル伝達の仕組み RO…
Dual oxidase 1 http://www.uniprot.org/uniprot/Q9NRD9 EC=1.11.1.- EC=1.6.3.1 Alternative name(s) Large NOX 1 / Long NOX 1 / NADPH thyroid oxidase 1 / Thyroid oxidase 1 Function Generates hydrogen peroxide which is required for the activity …
微生物の表面に存在する繰り返しスパーターンの分子構造を認識する仕組み。病原体関連分子パターンを認識する、パターン認識レセプターのひとつ。 血漿中のタンパク質として存在し、補体活性化のレクチン経路を開始することが出来る。コラーゲンに類似したド…
貪食細胞が、直接病原体の表面を認識する細胞表面レセプターのひとつ。 N末端にR型レクチンのドメインをひとつ、Ⅱ型フィブロネクチンドメインを挟んでC型レクチンドメインを８つ連ねている。４，５番目のC型レクチンドメインがマンノース、GlcNAc、フコース…
Ricin Cleaved into the following 3 chains: Ricin A chain EC=3.2.2.22 (Alternative name(s):rRNA N-glycosidase) Linker peptide Ricin B chain Organism Ricinus communis (Castor bean) Function Ricin is highly toxic to animal cells and to a less…
Prothrombin EC=3.4.21.5 Alternative name(s) Coagulation factor II Cleaved into the following 4 chains Activation peptide fragment 1 / Activation peptide fragment 2 / Thrombin light chain / Thrombin heavy chain Function Thrombin, which clea…
Antithrombin-III 血漿中に含まれる4種類のトロンビン阻害物質のうちの主要なもの（他にα2-マクログロブリン、ヘパリン補因子2、α1-アンチトリプシン）。硫酸化グリコサミノグリカン（ヘパリン）がアンチトロンビンの陽電荷部位に結合し、立体構造が変化して…
Androgen receptor Alternative name(s): Dihydrotestosterone receptor Nuclear receptor subfamily 3 group C member 4 Gene names Name: AR Synonyms: DHTR, NR3C4 Function Steroid hormone receptors are ligand-activated transcription factors that …
Vitamin D3 receptor Short name=VDR Alternative name(s): 1,25-dihydroxyvitamin D3 receptor Nuclear receptor subfamily 1 group I member 1 Gene names Name: VDR Synonyms: NR1I1 Function Nuclear hormone receptor. Transcription factor that media…
Thyroid hormone receptor alpha Alternative name(s): Nuclear receptor subfamily 1 group A member 1 V-erbA-related protein 7 Short name=EAR-7 c-erbA-1 c-erbA-alpha Gene names Name: THRA Synonyms: EAR7, ERBA1, NR1A1, THRA1, THRA2 Function Nuc…
Mineralocorticoid receptor http://www.uniprot.org/uniprot/P08235 Short name=MR Alternative name(s): Nuclear receptor subfamily 3 group C member 2 Function Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (G…
Steroid hormone receptor ERR1 Alternative name(s) Estrogen receptor-like 1 / Estrogen-related receptor alpha Short name=ERR-alpha Nuclear receptor subfamily 3 group B member 1 Gene names Name: ESRRA Synonyms: ERR1, ESRL1, NR3B1 Function エ…
Retinoic acid receptor alpha Short name=RAR-alpha Alternative name(s): Nuclear receptor subfamily 1 group B member 1 Gene names Name: RARA Synonyms: NR1B1 Function 全トランス、または9-cisレチノイン酸をリガンドとするRXRとRARがヘテロダイマー…
Glucocorticoid receptor Short name GR (Alternative name(s):Nuclear receptor subfamily 3 group C member 1) Function Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid respons…
Peroxisome proliferator-activated receptor gamma Short name=PPAR-gamma Alternative name(s): Nuclear receptor subfamily 1 group C member 3 Gene names Name: PPARG Synonyms: NR1C3 Function 高脂血症治療薬、脂肪酸などペルオキシソーム増殖因子の…
http://www.uniprot.org/uniprot/P17612 四次構造 数種類の不活性な四量体ホロ酵素はホモまたはヘテロに量体を形成する調節サブユニットと2分子の触媒サブユニットの組み合わせによる。cAMPは調節サブユニット二量体に四分子のcAMPが結合し、調節サブユニッ…
http://www.uniprot.org/uniprot/?query=%28adenylate+cyclase%29+AND+reviewed%3Ayes+AND+organism%3A%22Homo+sapiens+%5B9606%5D%22&sort=score EC=4.6.1.1 Adenylate cyclase type 1 This is a calmodulin-sensitive adenylyl cyclase. May be involved i…
99-36 尿談合成に係わる酵素を選択的に阻害する薬物はどれか。
Mercaptopurine Mechanism of action Mercaptopurine competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is itself converted to thioinosinic acid (TIMP). This intracellular nucle…
Cytidine deaminase EC=3.5.4.5 Alternative name(s): Cytidine aminohydrolase Uridine phosphorylase Short name=UPase EC=2.4.2.3 Function Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deo…
Guanine deaminase Short name=Guanase Short name=Guanine aminase EC=3.5.4.3 Alternative name(s): Guanine aminohydrolase Short name=GAH p51-nedasin Function Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia By s…
Purine nucleoside phosphorylase Short name=PNP EC=2.4.2.1 Alternative name(s): Inosine phosphorylase Inosine-guanosine phosphorylase Gene names Name: PNP Synonyms: NP Function The purine nucleoside phosphorylases catalyze the phosphorolyti…
EC=3.1.3.5 さまざまな基質特異性、反応特異性、細胞内局在をもつヌクレオチダーゼが存在し、細胞内のヌクレオシド濃度を保つ。 Cytosolic 5'-nucleotidase 1A / Short name=cN1A :Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides a…
Thymidylate synthase Short name=TS Short name=TSase EC=2.1.1.45 Function Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Ref.13 Catalytic activity 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAM…
TPA応答配列に結合する転写因子。Jun関連遺伝子、Fos関連遺伝子の産物からなるヘテロ二量体が主な成分となっている。 TPA応答配列 ホルボールエステル（12-O-テトラデカノイルホルボール13-アセテートなど）で細胞を刺激することで転写が活性化される遺伝子…
Thioredoxin reductase 1, cytoplasmic Short name=TR EC=1.8.1.9 Alternative name(s): Gene associated with retinoic and interferon-induced mortality 12 protein Short name=GRIM-12 Short name=Gene associated with retinoic and IFN-induced mortal…
Ribonucleoside-diphosphate reductase large subunit http://www.uniprot.org/uniprot/P23921 EC=1.17.4.1 Alternative name(s): Ribonucleoside-diphosphate reductase subunit M1 Ribonucleotide reductase large subunit Function Provides the precurso…
Hypoxanthine-guanine phosphoribosyltransferase Short name=HGPRT Short name=HGPRTase EC=2.4.2.8 Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribos…
キノン (quinone) は、一般的にはベンゼン環から誘導され、2つのケトン構造を持つ環状の有機化合物の総称である。
CAD protein http://www.uniprot.org/uniprot/P27708 This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). Including the following 3 domains: Glutamine-dependent c…
