Adenylate cyclase type 1
- This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.
- Enzyme regulation
- Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex.
type 2
- This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.
- Cofactor
- Binds 2 magnesium ions per subunit By similarity.
- Enzyme regulation
- Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex By similarity. Phosphorylation by RAF1 results in its activation. Ref.6
- Subunit structure
- Interacts with RAF1. Ref.6
- Subcellular location
- Membrane; Multi-pass membrane protein.
- Tissue specificity
- Expressed in brain.
- Post-translational modification
- Phosphorylated by RAF1.
type 3
- Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.
- Cofactor
- Binds 2 magnesium ions per subunit By similarity.
- Enzyme regulation
- Activated by calcium/calmodulin.
- Subcellular location
- Membrane; Multi-pass membrane protein.
- Tissue specificity
- Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
