AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated …

Function Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Want signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating gl…

Glycogen phosphorylase, liver form Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phospho…

GLUT1 Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Detected i…

カリクレイン重鎖と軽鎖に切断される The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may a…

1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and pl…

www.uniprot.org血液凝固の開始、線溶、ブラジキニンとアンギオテンシンの生成に関与する。 プレカリクレインは第Ⅻ因子により切断されカリクレインとなる。カリクレインはトリプシンとともに第Ⅻ因子を活性化する。第Ⅻ因子は第Ⅺ因子を活性化する。 Factor XII…

プラスミノーゲンは血栓のフィブリンを溶解するほか、多くの過程でタンパク質分解因子として働く。（胎児の発達、組織のリモデリング、腫瘍の浸潤、炎症など） 排卵ではグラーフ卵胞の破裂を促す。ウロキナーゼ型のプラスミノーゲンアクチベーター、コラゲナ…

http://www.uniprot.org/uniprot/P51617 Function Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is…

外因性の血液凝固の開始に係わる。セリンプロテアーゼで血液中をチモーゲンとして循環している。第Xa,XIIa, IXa因子、トロンビンにより活性型のVIIa因子に変換される。組織因子とカルシウムイオンの存在下で、第VIIa因子は第X因子を限定分解で活性型Xaに変換…

meal 食事（一食分）、料理、食べ物 feed 食べさせる、エサを与える、給仕する、食べさせる diet 日常の飲食物、食事、食物、治療食 food 食物、食料、食糧、飲み物に対する食べ物 dietary 食事の、食事療法の nutrition 栄養物摂取、栄養、栄養物、食物、栄…

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density li…

Prolyl 4-hydroxylase subunit alpha-1 Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Catalytic activity L-proline-[procollagen] + 2-oxoglutarate + O2 = trans-4-hydr…

ATP-binding cassette sub-family A member 1 cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport. ATP-binding cassette sub-family G member 1 Transporter involved in macr…

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Facilitates the flux of free and esterified cholesterol betw…

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Ac…

Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL wh…

Apo A 肝臓および小腸で合成分泌される。キロミクロンとHDLの成分。 Apo A-I Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor f…

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL) (PubMed:27578112). Binding to heparin sulfate proteogylcans at the cell surface is vital to the fun…