Angiotensinogen https://www.uniprot.org/uniprot/P01019 Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: acts directly on vascular smooth…
ghrelin Growth hormone secretagogue Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulate…
Vasopressin V2 receptor Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. https://www.uniprot.org/uniprot/P30518 Vasopressin V…
ATP-sensitive inward rectifier potassium channel 11 IKATP This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it…
Platelet glycoprotein Ib alpha chain 血小板の表面にあり、VWFのA1ドメインと結合して血小板血栓形成に働く。 GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, wh…
骨組織は、破骨細胞による吸収除去と骨芽細胞による新生骨の形成（リモデリング）により作られる。 破骨細胞の前駆細胞はRANK（受容体）をもち、リガンド（RANKL）の結合により成熟する。 https://seikagaku.jbsoc.or.jp/10.14952/SEIKAGAKU.2019.910529/dat…
https://www.uniprot.org/uniprot/P35558 Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:3019…
イオンチャネル型 AMPA受容体 カイニン酸受容体 NMDA受容体 代謝型グルタミン酸受容体 グループⅠ グループⅡ グループⅢ
Hormone-sensitive lipase https://www.uniprot.org/uniprot/Q05469 EC:3.1.1.79 Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters…
Short-chain specific acyl-CoA dehydrogenase, mitochondrial https://www.uniprot.org/uniprot/P16219 EC:1.3.8.1 Butyryl-CoA dehydrogenase Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the firs…
kallikrein-1 Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykini…
https://www.uniprot.org/uniprot/P29590 Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA dam…
https://www.uniprot.org/uniprot/P20396 As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as m…
https://www.uniprot.org/uniprot/P41159Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in t…
- https://www.uniprot.org/uniprot/Q15848 Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation a…
Alpha-2A adrenergic receptor Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonid…
https://www.uniprot.org/uniprot/P50552 Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, pl…
CS MALLTAAARL LGTKNASCLV LAARHAS PDH MRKMLAAVSR VLSGASQKPA SRVLVASRN Fumarate hydratase MYRALRLLAR SRPLVRAPAA ALASAPGLGG AAVPSFWPPN AARM Long-chain specific acyl-CoA dehydrogenase MAARLLRGSL RVLGGHRAPR QLPAARCSHS Pyruvate carboxylase MLKFR…
https://www.uniprot.org/uniprot/P25116 活性化されたトロンビンと高い親和性で結合し、Gq経由でホスホイノシチドを加水分解する。血小板の活性化と血管の発達に働く。 High affinity receptor for activated thrombin coupled to G proteins that stimulat…
https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC6/cont6a.html EC 6.1 Forming Carbon-Oxygen Bonds EC 6.1.1 Ligases Forming Aminoacyl-tRNA and Related Compounds EC 6.1.1.1 tyrosine—tRNA ligase EC 6.1.1.2 tryptophan—tRNA ligase EC 6.1.1.3 threonin…
https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC5/cont5a.html EC 5.1 Racemases and Epimerases EC 5.1.1 Acting on Amino Acids and Derivatives EC 5.1.1.1 alanine racemase EC 5.1.1.2 methionine racemase EC 5.1.1.3 glutamate racemase EC 5.1.1.4 pro…
https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC4/cont4a.html EC 4.1 Carbon-Carbon Lyases EC 4.1.1 Carboxy-Lyases EC 4.1.1.1 pyruvate decarboxylase EC 4.1.1.2 oxalate decarboxylase EC 4.1.1.3 now EC 7.2.4.2 and EC 4.1.1.112 EC 4.1.1.4 acetoacet…
https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC3/cont3aa.html https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC3/cont3bb.htmlEC3群（加水分解酵素、ヒドロラーゼ） 小群１（EC3.1)：エステル結合の加水分解 （EC3.1.1.x）：カルボン酸エステルの加水分解 （EC3…
https://www.qmul.ac.uk/sbcs/iubmb/enzyme/ EC 2.1 Transferring One-Carbon Groups EC 2.1.1 Methyltransferases EC 2.1.1.1 nicotinamide N-methyltransferase EC 2.1.1.2 guanidinoacetate N-methyltransferase EC 2.1.1.3 thetin—homocysteine S-methyl…
EC 1.1 Acting on the CH-OH group of donors（小群１：アルコール性水酸基が電子を放出） EC 1.1.1 With NAD+ or NADP+ as acceptor（組１：NAD+またはNADP+が電子を受容） EC 1.1.1.1 alcohol dehydrogenase EC 1.1.1.2 alcohol dehydrogenase (NADP+) EC …
EC 7.1 Catalysing the translocation of hydrons（水素イオンを移動させる） EC 7.1.1 Hydron translocation or charge separation linked to oxidoreductase reactions（酸化還元反応を伴う） EC 7.1.1.1 proton-translocating NAD(P)+ transhydrogenase E…
ようやく、来週月曜日（4月20日）から講義が始まります。 ムードルも今まで全く使っていなかったので、急遽用意しました。 もし、アクセスが混んでいてうまく繋がらない時のために、こちら側にも講義資料等へのリンクをしておきます。 （練習問題の方は、Moo…
最小有効量（ED0） 薬理効果が現れる最小の量 極量（ED100） 全ての個体が反応する量 50％有効量（ED50） 半分の個体が反応する量で、薬物の薬効の強さの指標となる。 耐量（LD0） 個体が死に至る最小の量 50％致死量（LD50） 半数が死亡する薬物量で、小さ…
血液の緩衝作用は重炭酸塩が重要である。 血液の重炭酸塩による緩衝作用は以下の2つの平衡による。 CO2 + H2O H2CO3 (1) H2CO3 H+ + HCO3- (2)この2つの反応の全体としてのpKは6.35である。 肺 代謝によってH+が生じると、(2)の平衡が左に傾き、、(1)の平衡…
Phosphatidylcholine-sterol acyltransferase Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) t…
