Platelet glycoprotein Ib alpha chain
血小板の表面にあり、VWFのA1ドメインと結合して血小板血栓形成に働く。
GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
UniProt
Platelet glycoprotein VI
GPVI
コラーゲンの受容体としてコラーゲンによりもたらされる血小板の粘着と活性化に関与する。血小板の血液凝固前活性と引き続き起こるトロンビンとフィブリンの形成に重要。動脈や静脈で血栓を作るのに役割を果たす。
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
https://www.uniprot.org/uniprot/Q9HCN6
Platelet glycoprotein V
GPV
糖タンパク質1b-V-IX複合体の中でvWFに依存する血小板の血管への粘着に機能する。
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.
https://www.uniprot.org/uniprot/P40197
Platelet glycoprotein IX
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.
https://www.uniprot.org/uniprot/P14770
Proteinase-activated receptor 1
PAR-1
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
https://www.uniprot.org/uniprot/P25116
Proteinase-activated receptor 4
PAR-4
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
https://www.uniprot.org/uniprot/Q96RI0
Thromboxane A2 receptor
TXA2-R
Prostanoid TP receptor
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
https://www.uniprot.org/uniprot/P21731
Prostacyclin receptor
PGI receptor
Prostanoid IP receptor
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. (Caution: Palmitoylation of either Cys-308 or Cys-311 was reported to be sufficient to maintain functional coupling to G(s) proteins and signaling (PubMed:12488443). However, this publication was retracted due to figure duplication.)
https://www.uniprot.org/uniprot/P43119
P2Y purinoceptor 1
P2Y1
ADP receptor
Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790).
In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).
3 Publications
Activity regulationi
ATP functions as antagonist and inhibits ADP-induced mobilization of Ca2+ (PubMed:9038354). The P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P inhibit downstream signaling mediated by mobilization of Ca2+ from intracellular stores, and platelet shape changes in response to extracellular ADP (PubMed:9442040).
https://www.uniprot.org/uniprot/P47900
P2Y purinoceptor 12
P2Y12 platelet ADP receptor
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation.
https://www.uniprot.org/uniprot/Q9EPX4
Integrin alpha-2
Platelet membrane glycoprotein Ia
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
https://www.uniprot.org/uniprot/P17301
Integrin beta-1
Glycoprotein IIa
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen.
Integrin beta-3
Platelet membrane glycoprotein IIIa
Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin.
https://www.uniprot.org/uniprot/O54890
Integrin alpha IIb
Platelet glycoprotein IIb
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
https://www.uniprot.org/uniprot/P08514
