Guanylate cyclase soluble subunit alpha-3
Short name=GCS-alpha-3
EC=4.6.1.2
Alternative name(s):
GCS-alpha-1
Soluble guanylate cyclase large subunit
Gene names
Name: GUCY1A3
Synonyms: GUC1A3, GUCSA3, GUCY1A1
Organism Homo sapiens (Human) [Reference proteome]
Taxonomic identifier 9606 [NCBI]
Taxonomic lineage Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Protein attributes
Sequence length 690 AA.
Sequence status Complete.
Protein existence Evidence at protein level
General annotation (Comments)
Enzyme regulation
Activated by nitric oxide in the presence of magnesium or manganese ions.
Subunit structure
Heterodimer of an alpha and a beta chain.
Subcellular location
Cytoplasm.
Miscellaneous
There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 1 guanylate cyclase domain.
Guanylate cyclase soluble subunit beta-1
Short name=GCS-beta-1
EC=4.6.1.2
Alternative name(s):
Guanylate cyclase soluble subunit beta-3
Short name=GCS-beta-3
Soluble guanylate cyclase small subunit
Gene names
Name: GUCY1B3
Synonyms: GUC1B3, GUCSB3, GUCY1B1
Organism Homo sapiens (Human) [Reference proteome]
Taxonomic identifier 9606 [NCBI]
Taxonomic lineage Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Protein attributes
Sequence length 619 AA.
Sequence status Complete.
Protein existence Evidence at protein level
General annotation (Comments)
Catalytic activity
GTP = 3',5'-cyclic GMP + diphosphate.
Cofactor
Binds 1 or 2 heme groups per heterodimer By similarity.
Enzyme regulation
Activated by nitric oxide in the presence of magnesium or manganese ions.
Subunit structure
Heterodimer of an alpha and a beta chain.
Subcellular location
Cytoplasm.
Miscellaneous
There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 1 guanylate cyclase domain.
