Fucose-1-phosphate guanylyltransferase

EC=2.7.7.30

Alternative name(s):

GDP-L-fucose diphosphorylase
GDP-L-fucose pyrophosphorylase

Gene names

Name: FPGT
Synonyms: GFPP

Function

Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.

Catalytic activity

GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed in many tissues.