GDP-L-fucose synthase - biochook's diary

EC=1.1.1.271

Alternative name(s):

GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
Protein FX
Red cell NADP(H)-binding protein
Short-chain dehydrogenase/reductase family 4E member 1

Function

Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Ref.1

Catalytic activity

GDP-L-fucose + NADP+ = GDP-4-dehydro-6-deoxy-D-mannose + NADPH.

Pathway

Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.

Subunit structure

Homodimer. Ref.1

Sequence similarities

Belongs to the fucose synthase family.