1. Amidophosphoribosyltransferase EC=2.4.2.14
- Short name
- ATase
- Alternative name(s)
- Glutamine phosphoribosylpyrophosphate amidotransferase
- Short name
- GPAT
- regulation
- Activated by the substrate 5-phospho-alpha-D-ribosyl-1-pyrophosphate and inhibited by the purine ribonucleotides, the end products of purine biosynthesis. (rat enzyme)
2.3.5. Trifunctional purine biosynthetic protein adenosine-3
2. Phosphoribosylamine--glycine ligase
- EC
- 6.3.4.13
- Alternative name(s)
- Glycinamide ribonucleotide synthetase
- Short name
- GARS
Phosphoribosylglycinamide synthetase
- Catalytic activity
- ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138
3. Phosphoribosylglycinamide formyltransferase EC=2.1.2.2
- Alternative name(s)
- 5'-phosphoribosylglycinamide transformylase / GAR transformylase (Short name=GART)
- Catalytic activity
- 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
5. Phosphoribosylformylglycinamidine cyclo-ligase EC=6.3.3.1
- Alternative name(s)
- AIR synthase (Short name=AIRS) / Phosphoribosyl-aminoimidazole synthetase
- Catalytic activity
- ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.
4. Phosphoribosylformylglycinamidine synthase EC=6.3.5.3
- Short name
- FGAM synthase
- Short name
- FGAMS
- Alternative name(s)
- Formylglycinamide ribotide amidotransferase (Short name:FGARAT) / Formylglycinamide ribotide synthetase
- Catalytic activity
- ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
- Pathway
- Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.
- Subcellular location
- Cytoplasm.
6. 7. Multifunctional protein ADE2
6. Phosphoribosylaminoimidazole carboxylase EC=4.1.1.21
- Alternative name(s)
- AIR carboxylase (Short name=AIRC)
- Catalytic Activity
- 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
7. Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6
- Alternative name(s)
- SAICAR synthetase
- Catalytic Activity
- ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
7b. Adenylosuccinate lyase EC=4.3.2.2
- Short name
- ASL
- Alternative name(s)
- Adenylosuccinase (Short name=ASase)
- Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
- http://www.uniprot.org/uniprot/P30566
8.9. Bifunctional purine biosynthesis protein PURH
- Function
- Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
8. Phosphoribosylaminoimidazolecarboxamide formyltransferase
- EC=2.1.2.3
- Alternative name(s)
- 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase / AICAR transformylase
- Catalytic activity
- 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
9. IMP cyclohydrolase EC=3.5.4.10
- Alternative name(s)
- ATIC / IMP synthase / Inosinicase
- Catalytic activity
- IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
10. Adenylosuccinate synthetase isozyme
Adenylosuccinate synthetase isozyme 1 EC=6.3.4.4
Short name=AMPSase 1
Short name=AdSS 1
Alternative name(s):
Adenylosuccinate synthetase, basic isozyme
Adenylosuccinate synthetase, muscle isozyme
Short name=M-type adenylosuccinate synthetase
IMP--aspartate ligase 1
Adenylosuccinate synthetase isozyme 2
Short name=AMPSase 2
Short name=AdSS 2
EC=6.3.4.4
Alternative name(s):
Adenylosuccinate synthetase, acidic isozyme
Adenylosuccinate synthetase, liver isozyme
Short name=L-type adenylosuccinate synthetase
IMP--aspartate ligase 2
11. IMP dehydrogenase
Inosine-5'-monophosphate dehydrogenase 1
Short name=IMP dehydrogenase 1
Short name=IMPD 1
Short name=IMPDH 1
EC=1.1.1.205
Alternative name(s):
IMPDH-I
- Because IMPDH activity is tightly linked with cell proliferation, it has been recognized as a target for cancer and viral chemotherapy and as a target for immunosuppressive drugs. The activities of the antitumor drug tiazofurin, the antiviral drug ribavirin, and the immunosuppressive drugs mizoribine and mycophenolic acid (MPA) are attributed to the inhibition of IMPDH. In addition, bacterial and parasitic IMPDH's differ significantly from mammalian enzymes, which makes it a suitable target for anti-infective drugs.
- http://www.uniprot.org/uniprot/P20839
Inosine-5'-monophosphate dehydrogenase 2
Short name=IMP dehydrogenase 2
Short name=IMPD 2
Short name=IMPDH 2
EC=1.1.1.205
Alternative name(s):
IMPDH-II
12. GMP synthase [glutamine-hydrolyzing]
EC=6.3.5.2
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
