EC=3.4.23.15
Alternative name(s):
Angiotensinogenase
Function
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Catalytic activity
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
Enzyme regulation
Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.
