http://www.uniprot.org/uniprot/Q05469
EC=3.1.1.79
Function
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Catalytic activity
Diacylglycerol + H2O = monoacylglycerol + a carboxylate.
Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Monoacylglycerol + H2O = glycerol + a carboxylate.
Enzyme regulation
Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Subunit structure
Interacts with PTRF in the adipocyte cytoplasm. Ref.5
Subcellular location
Cell membrane. Membrane › caveola. Cytoplasm › cytosol. Note: Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. Ref.5 Ref.6
Post-translational modification
Phosphorylation by AMPK may block translocation to lipid droplets
