Acetyl-CoA carboxylase 1
Gene:ACACA, ACAC, ACC1, ACCA
function
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.1 Publication
Catalytic activityi
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.1 Publication
ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].1 Publication
Cofactori
Biotin.
Binds 2 manganese ions per subunit.
Enzyme regulationi
By phosphorylation By similarity. Activity is increased by oligomerization. Citrate and MID1IP1 promote oligomerization.1 Publication
Pathwayi
Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
