Alternative name(s):
N-acetylneuraminate synthase
EC=2.5.1.56
N-acetylneuraminate-9-phosphate synthase
EC=2.5.1.57
N-acetylneuraminic acid phosphate synthase
N-acetylneuraminic acid synthase
Gene names
Name: NANS
Synonyms: SAS
Function
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
Catalytic activity
Phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate.
Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate.
Tissue specificity
Ubiquitous.
Sequence similarities
Contains 1 AFP-like domain.
